During the opening stories, you'll get a bit of American style comic art to illustrate the story. This part would be great, except it looks so inconsistent, even within the same scene. It would be surprising if it were all done by the same artist. Someone was swapped out, whether it be colorist, inker or artist, someone was swapped out at some point.
Personal taste in art aside, the characters are pretty nicely made. The models push a level of detail that's pretty surprising on the Wii, and the backgrounds are fairly nice as well (of course, not pushing the kind of detail and movement you'd see in Street Fighter or the like). They do seem a bit stiff in animation, but still, rather well done.
Voices are another bit of disappointment. Everyone seems to have the same personality, the same corny sense of humor. Maybe this is just me wanting my gods and goddesses to be a bit more impressive, a bit more dignified. Or perhaps I just can't take my myths and legends telling me, "The man couldn't keep me down!"