Nancy Drew: Legend of the Crystal Skull starts off with our little heroine and her best friend cashing in some frequent flyer miles to go to New Orleans and stay with a friend.
And, in true Nancy Drew fashion, the pair of girls stumbles upon a new mystery. Bruno Bolet is a wealthy man and owner of a crystal skull called "Whisperer." Legend has it that this particular skull's magical abilities keep the owner from dying, well unless he or she is murdered. When Bruno dies and his wealth (and supposedly the skull) is passed down to his nephew, Henry, the crystal skull seems to be missing.
So now, Nancy and Bess decide to start trying to solve this new mystery. Along the way, you will meet characters like Renee, the housekeeper, Lamont, an antique shop owner and Gilbert, Bruno's best friend. It seems like everyone the duo meets in this game has motive to take the missing skull, and possible even kill Bruno.
This game is very much a standard point-and-click adventure title. You will find yourself talking with many people and collecting various random items in order to piece together the mystery. One of the good things about these Nancy Drew games is that the plot and mystery are fairly well laid out; after all, if they weren't, then the books wouldn't be anywhere near the classics that they are.
Where these games tend to differ from other adventure titles is the inclusion of some mini-games that you need to complete in order to advance the storyline. These mini-games involve bowling, getting out of the way of chomping teeth (don't ask) and getting rid of wasps. These games come fairly regularly and break up the monotony a bit.