Once again, the player is dropped into the role of Domingo "Ding" Chavez, one of the leaders of Rainbow Team. At the start of each mission, a squad of up to three fellow operatives is chosen to back you. A good portion of the mission work involves giving the squad orders to clear out rooms, defuse live bombs, and take down enemies. Most missions can be completed successfully even if the entire backing squad is killed off, which opens up the door for decoy or friendly diversion work with disposable members of the squad in a pinch.
Some missions allow the player to assume the role of Dieter Weber, Rainbow team sniper, which provides a break in the tension with some shooting gallery style action, as your mission is to provide cover for the strike team.
The entire campaign consists of 16 missions which when completed, open up further play options within the mission levels. These include: Terrorist Hunt, in which the object is to simply take out all of the enemy terrorists on the map. Lone Rush, in which the goal is to reach the extraction point before time runs out. Infiltrator, where the goal is to simply disable all of the cameras on a level before venturing toward the extraction point and lastly Sniper Campaign allows you to hone your targeting abilities on the levels that contained Dieter's sniping component.
Rainbow Six: Lockdown has no shortage of options or mission variation to keep the player occupied.