The game engine that the developers were able to put together is very, very impressive. The scrolling is smooth, crisp and detailed. I was especially impressed with the amount of interactive elements in the game. Plants catch fire when you shoot them, computers smash, barrels explode, toilets become geysers, and walls show damage. At times, you can even look at camera monitors to see into other rooms. Of course, all of these details are displayed in a very low resolution and come off as muddy and pixilated, but when you consider the system, I don't see how anyone could be that disappointed.
Considering the limitations of a cartridge, Duke Nukem Advance does a great job of cramming as much sound as it can into the game. Most of Duke's sayings are present, although toned down a bit, as well as some great weapon effects and nice music.