Ar tonelico II: Melody of Metafalica is a direct sequel to the 2006 RPG and takes place a year after the first game. The game takes place in the same world, though in different region, Metafaluss, which surrounds a new tower, Infel Pira. Despite geographical differences, the game's world still involves the song-battling Reyvateils, who are falling victim to a mysterious virus called Infel Pira Dependency (IPD). Once the virus sets in, it slowly drives the song maidens insane, eventually killing them. Playing as a young knight from the Grand Bell Hall, Croix, you are charged with figuring out what is causing the problem and hopefully eliminating it.